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NCJ Number: 250125 Find in a Library
Title: Bath Salt-type Aminoketone Designer Drugs - Analytical and Synthetic Studies on Substituted Cathinones
Author(s): Randall Clark
Date Published: July 2016
Page Count: 28
Sponsoring Agency: National Institute of Justice (NIJ)
Washington, DC 20531
US Dept of Justice NIJ Pub
Washington, DC 20531
Grant Number: 2013-DN-BX-K022
Sale Source: US Dept of Justice NIJ Pub
810 Seventh Street, NW
Washington, DC 20531
United States of America
Document: PDF
Type: Report (Grant Sponsored); Report (Study/Research); Research (Applied/Empirical)
Format: Document; Document (Online)
Language: English
Country: United States of America
Annotation: This project focused on issues of resolution and discriminatory capabilities needed to increase the reliability and selectivity of forensic evidence and analytical data for new analytes of the so-called bath salt-type drugs of abuse.
Abstract: The improvement sought in the project comes from the development of methods that allow forensic analysts to identify specific regioisomeric forms of substituted aminoketones among many isomers of mass spectral equivalence. The project provides methodology and analytical data necessary to discriminate between those regiosomeric and isobaric molecules having the same molecular weight and major fragments of equivalent mass, i.e., identical mass spectra. This work has anticipated the future appearance of some designer aminoketones and developed reference data and analytical reference standards for these compounds. Project results will increase the forensic drug chemistry knowledge base for aminoketone-type designer drugs. When compounds produce the same mass spectrum as the drug of interest, the identification by GC-MS must be based upon the ability of the chromatographic system to resolve these substances. This project included the synthesis and generation of complete analytic profiles and methods of differentiation for regioisomeric and isobaric substances related to the substituted aminoketones. The project has succeeded in generating proactive data for the forensic drug analyst and in describing a unified approach for specific drug identification based on structure correlated analytical properties. Mass spectra and product ion spectra are provided to show the results for the egoistic cyclic tertiary amines related to MDPV (3,4-methylenedioxypyrovalerone). 5 figures
Main Term(s): Drug detection
Index Term(s): Designer drugs; Drug analysis; Drug law enforcement; Investigative techniques; NIJ final report; NIJ Resources
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=272285

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